Polynerv Drops

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Thiamine HCl (Vit. B1)

Pyridoxine HCl (Vit. B6)

Cyanocobalamin (Vit. B12)


Syrup (Oral Drops)




Each mL contains:

Thiamine HCl (Vit. B1) ………… 10 mg
Pyridoxine HCl (Vit. B6) ………… 2 mg
Cyanocobalamin (Vit. B12) ………… 25 mcg
Lemon-orange flavor


Vitamins B1+B6+B12 (Polynerv) oral drops is a high potency formulation of three important neurotrophic and growth factors: vitamins B1, B6 and B12.


Water soluble vitamins like B1, B6 and B12 are frequently inadequate in unbalanced diets. Even children who take substantial amounts of the B vitamins in the diet may suffer from deficiency disorders resulting from impaired B vitamins absorption (as in excessive vomiting, prolonged antibiotic therapy and intake of certain agents which interfere with the utilization of B vitamins i.e. isoniazid).

Normal cellular activities depend on the availability of biochemical energy derived mainly from the metabolism or transformation of nutrients. Vitamins B1, B6 and B12, as coenzymes, help the enzymes accelerate the various metabolic processes which produce energy. This energy is used to fuel the cellular activities of the body especially those of the activities of the nervous system.

The metabolic events where vitamins B1, B6 and B12 play dominant roles as cofactors make possible the conversion of food nutrients (carbohydrates, fats and proteins) into utilizable substances needed for synthesis of body tissues and compounds. Formation of body tissues and compounds effects growth manifested as weight gain and height increase.

It is also believed that vitamins B1, B6 and B12 possess neurotrophic properties. Vitamins B1, B6 and B12 activate specific biochemical pathways involved in normal nervous system physiology.

Thiamine (vitamin B1) operates inside the body as cocarboxylase, a coenzyme involved in the intermediary metabolism of glucose to produce energy. Glucose is the body’s chief source of energy. It also ensures the storage of energy as fat, and the conversion of glucose into other substances such as ribose, a major component of deoxyribonucleic acid (DNA), which is involved in cellular replication and multiplication.

Thiamine is essential for maintaining proper functioning of the three major systems of the body. It makes energy available to support normal growth and to fuel the activities of the central nervous system, secretory glands and the smooth muscle cells of the gastrointestinal tract and cardiovascular system. Thiamine improves muscle tone of the intestines, stomach and heart.

Glucose provides the basic nutritional needs of the nervous system. The cells of the central nervous system depend exclusively on glucose as its fuel source. Thiamine is said to optimize brain function and cognitive activity thereby exerting a positive effect on the child’s learning capacity. Independent of its coenzyme function, vitamin B1 acts as a modulator in the transmission of neural impulses.

Effects of thiamine deficiency include fatigue, constipation, irritability, headache and mental confusion.

Pyridoxal phosphate, the active form of vitamin B6, plays a key role in the metabolism of amino acids. Amino acids as building blocks of proteins, are in turn necessary for the formation of body tissues and regulatory compounds. Specifically, pyridoxal phosphate participates in the synthesis of heme and globin which are components of the hemoglobin molecule, the oxygen carrying pigment of the blood.

Vitamin B6 is required as a cofactor in the synthesis of neurotransmitters such as serotonin, GABA and epinephrine, which are all important regulatory substances of the nervous system. Vitamin B6 is required as a cofactor in the synthesis of gamma aminobutyric acid(GABA) in the brain. GABA, an inhibitory neurotransmitter derived from glutamic acid, is important in maintaining the normal activity of the brain. GABA decreases neuronal activity and inhibits nerve cells from overfiring. The threshold for seizures is lowered when the brain concentration of GABA is reduced in vitamin B6 deficiency.

Pyridoxine deficiency disturbs cerebral metabolism and causes abnormal nervous system function with hyperirritability, neuritis and possibly convulsions.

Vitamin B6 supplementation is important in the management of anemia and also for those patients who are being treated with isoniazid (INH), a widely used antituberculosis drug. Excessive dose of INH can induce B6 deficiency because INH interferes with utilization of B6 by forming a hydrazone with pyridoxal.

Polynerv oral drops provides substantial concentration of cyanocobalamin (vitamin B12). Vitamin B12 acts as a coenzyme of nucleic acid metabolism, reducing ribonucleotides to deoxyribonucleotides, a step that is essential in gene replication and formation of new cells and tissues. Vitamin B12 is therefore an important growth factor. It also promotes the formation and maturation of red blood cells in the bone marrow.

The physical and mental well-being of the growing child largely depends upon the maintenance of a normally functioning nervous system.

Vitamins B1, B6 and B12 (Polynerv) oral drops help enhance nourishment of neuronal cells and promote normal nervous system physiology. Optimum nutrition of neuronal cells is a must in the management of diseases affecting the nervous system. If the neuronal cells are deprived of the basic nutritional needs, cellular reactions will be impaired and the physiologic activities of the other organs will be affected.

The B vitamins, by virtue of their biologic function as metabolic activators, provide natural neurotrophic support in the management of a wide range of disorders arising from increased tissue demands. They are also useful in situations when there is increased requirement for energy as in growth, strenuous physical activities, stress during illnesses such as hypermetabolic states and infectious diseases.


Vitamins B1, B6 and B12 (Polynerv) oral drops is valuable in conditions where the requirements for B vitamins are increased as in growth, physiologic stress, decreased resistance to infection and chronic illnesses, metabolic disorders and in certain diseases of the digestive tract and nervous system. It can also be given before and after surgical procedures.

Vitamins B1, B6 and B12 (Polynerv) oral drops is indicated for the prevention and treatment of deficiency disorders arising from poor dietary intake, impaired B vitamin absorption as in prolonged diarrhea, excessive vomiting and antibiotic therapy, intake of drugs which interfere with the utilization of the B vitamins (i.e. isoniazid).

As a nutritional supplement to promote appetite, weight gain and height increase.


0 – 6 mos. = 0.5 mL – 1.0 mL
7 mos. – 1 yr. = 1.0 mL – 1.5 mL
1 – 2 yrs. = 1.5 mL – 2.0 mL

To be taken once daily or as prescribed by the physician.


Regular monitoring of blood is required when taking vitamin B12. Administration of doses greater than 10 mcg daily may produce haematological response in patients with folate deficiency. Vitamin B12 should not be used for Lefer’s disease or tobacco amblyopia since those optic neuropathies may degenerate further.